摘要
用ＳＤ大鼠造成实验性高血压糖尿病（ＨＤ）后，分别于６、８和１０个月处死，每组８例，用光镜及透射电镜动态观察心脏变化。结果提示：首先出现，心脏小动脉壁增厚、腔变窄，随后出现心肌细胞的变性或坏死，以及替代性纤维化和间质性纤维化。并对扩张型心肌病的病理形态学发生机理作了探讨。
An experimental model of hypertensive diabetes in SD rats was established.Eight animals in each group were respectively killed at the end of the sixth,eight and tenth month of the experimental period.The heart changes were dynamically observed under light microscope and transmissive electronmicroscope.The arteriolar walls were thickened with lumina narrowed.Degeneration,necrosis and fibrosis(substitutional and interstitial)of the myocardium were found also. Adiscussion is given on morphological pathogenesis of dilated cardiomyopathy.
基金
国家自然科学基金
关键词
高血压
糖尿病
心肌病
超微结构
hypertensive diabetes
cardiomyopathy
ultrastructure
myocardial necrosis
fibrosis
rat
