5－Fu、Cimetidine对急性胰腺炎患者的免疫调节作用

THE IMMUNE ADJUSTMENT OF 5-Fu CIMETIDINE ON THE ACUTE PANCREATITIS CASES

应用单克隆抗体技术测定４５例急性胰腺炎外周血Ｔ淋巴细胞亚群，通过对５－Ｆｕ、Ｃｉｍｅｔｉｄｉｎｅ治疗组和抑肽酶治疗组的对照分析以及治疗后的动态观察发现：急性胰腺炎患者存在细胞免疫平衡紊乱，表现为１４↓、Ｔ８↑、Ｔ４／Ｔ８↓，治疗组于治疗后７～９天起Ｔ细胞亚群恢复，而对照组仅Ｔ４恢复，认为急性胰腺炎免疫平衡紊乱可能是感染性易感性增高的原因之一。５－Ｆｕ、Ｃｉｍｅｔｉｄｉｎｅ不仅能有效地抑制胰腺外分泌功能，还可改善患者免疫状况，提高抗感染能力。

The T-lymphocyte subsets in peripheral blood of 45 cases with acute pancretitis have been analysed by monoclonal antibody.The treatment with 5-Fu,Cimetidine has been compared with aprotinin. The result is that there is cell immunity disorder with the patients of acute pancreatitis.It appears that there is a signifieant decrcase in T4,T4/T8 ratio,and increase in T8.T-lymphocyte subsets in treatment group with 5-Fu,Cimetidine recovered after 7-9 days;in the contrast group only T4 recovered.So it is considered that the immune disorder in acute pancrcatitis cases is probably the cause of high infectious susceptibility.5-Fu,Cimetidine can not only restrain the function of pancrcas exocrine,but also improve the immunity state and enhance the ability of infection resistance.