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5-Fu、Cimetidine对急性胰腺炎患者的免疫调节作用

THE IMMUNE ADJUSTMENT OF 5-Fu CIMETIDINE ON THE ACUTE PANCREATITIS CASES
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摘要 应用单克隆抗体技术测定45例急性胰腺炎外周血T淋巴细胞亚群,通过对5-Fu、Cimetidine治疗组和抑肽酶治疗组的对照分析以及治疗后的动态观察发现:急性胰腺炎患者存在细胞免疫平衡紊乱,表现为14↓、T8↑、T4/T8↓,治疗组于治疗后7~9天起T细胞亚群恢复,而对照组仅T4恢复,认为急性胰腺炎免疫平衡紊乱可能是感染性易感性增高的原因之一。5-Fu、Cimetidine不仅能有效地抑制胰腺外分泌功能,还可改善患者免疫状况,提高抗感染能力。 The T-lymphocyte subsets in peripheral blood of 45 cases with acute pancretitis have been analysed by monoclonal antibody.The treatment with 5-Fu,Cimetidine has been compared with aprotinin. The result is that there is cell immunity disorder with the patients of acute pancreatitis.It appears that there is a signifieant decrcase in T4,T4/T8 ratio,and increase in T8.T-lymphocyte subsets in treatment group with 5-Fu,Cimetidine recovered after 7-9 days;in the contrast group only T4 recovered.So it is considered that the immune disorder in acute pancrcatitis cases is probably the cause of high infectious susceptibility.5-Fu,Cimetidine can not only restrain the function of pancrcas exocrine,but also improve the immunity state and enhance the ability of infection resistance.
出处 《南通医学院学报》 1994年第4期437-439,共3页 ACTA Academiae Medicinae Nantong
关键词 急性 胰腺炎 5-FU CIMETIDINE 免疫调节 acute pancreatitis 5-Fu cimetidine T-lymphocyte subsets immune adjustment
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