氨苄青霉素在鹅体内的药代动力学及其组织残留研究

STUDIES OF PHARMACOKINETICS AND DRUG RESIDUES OF AMPICILLIN IN GEESE

氨苄青霉素。按20mg/kg的剂量给鹅肌注和静注,于不同时间采血和剖杀。用荧光分光光度法测定血浆和各组织中的药物浓度。血液中的药时数据符合有吸收因素二室开放模型(肌注组)以及无吸收因素二室开放模型(静注组),用药后72小时,药物在肌、心和肝等组织中的残留量已低于F.A.O/W.H.O.所规定的最大容许残留量(0.06μg/g)。

Ampicillin sodium was administered intramuscularly or intravenously to seventy-one geese at a single dosage of 20mg/kg. Blood and tissue samples were collected at different intervals after the drug was given. Amipicillin in the plasma and the tissue was determined by spectrofluorometer.In IM group, the blood concentration versus time data could be described by the two-compartment open model with absorption factor. In Ⅳ group, pharmackinetic characteristics of ampicillin was dascribed by using two-compartment open model without absorption factor.In the drug residues study, it was found that after the drng was given for 72 hrs the ampieillin in liver and heart as well as muscle was below the maximnm acceptable level suggested by F.A.O/W.H.O.