腹腔灌洗在治疗急性坏死性胰腺炎中的作用

Effects of intraperitoneal perfusion on the treatment of acute necrotic pancreatitis

作者用健康杂种狗１８条，采用狗自身胆汁和胰蛋白酶混合液从胰管逆行注射的方法制做出“急性坏死性胰腺炎”的模型。随机分为两组：Ａ组８条狗，仅给支持治疗；Ｂ组１０条狗在支持治疗基础上给予腹腔灌洗。结果：支持治疗组８条狗平均仅存活２６±３小时，存活率为０％；而灌先组１０条狗中４条死亡（平均存活４０±１８小时），６条存活，存活率为６０％。作者采用腹腔灌洗的方法治疗１４例急性坏死性胰腺炎，有７例因病情恶化疑有感染或出现并发症而中转手术，其中４例治愈，３例死亡；另７例，６例完全治愈，１例死亡。作者认为腹腔灌洗适应于急性坏死性联腺炎的早期病例，即坏死尚未感感的病例。

Abstract Hybrid dogswereused inthis study. The model of acute necrotic duct injection of amixture of seyf-bila and trypsin. All the animals were randomly divided into two groups. Group A, 8 dogs with supporting therapy only,and Group B, 10 dogs with both supporting therapy and intraperitoneal perfusion. The results: Tge mean survival period of group A was 26±3hours Thesurvival rate was zero. Ingroup B 6out of 10 were survived and 4 dead (mean survival period 40±18 hour). 14 cases of acute necrotio pancreatitis received intraperitoneal perfusion trestment. 7 out of 14 casesunderwent operation because ofinfection or other complications, among them 4 were cured and 3 dead while in other 7 cases 6 were cured and ldead. The indication of this therapy was the early stage of the disease ie, no secondaryinfection cases.