摘要
本文对医药邻─(2,6─二氯苯胺基)─苯乙酸钠的中间体N─苯基─2,2,6,6─四氯环己亚胺的合成工艺进行了系统研究,对该反应的催化剂种类、用量、原料配比、缩合温度等。艺条件进行了分析探讨,找出了较佳合成工艺条件,并对产品结构进行了认证。
N-phenly-2, 2, 6. 6-tetrachlorocyclohexaneimine is a intermediate of diclofenac sbdium. The synthetic processes of N-phenly-2, 2. 6. 6-tetrachlorocyclohexaneimine were studied in this paper.the kinds and amount of catalyst used, material ratio,temperature of reaction were discussed. Some outstanding processes were obtained.