高血压病人红细胞变形能力与红细胞ATP酶活性及细胞内离子水平关系的研究

STUDY ON RELATIONSHIP BETWEEN ERYTHROCYTE DEFORMABILITY AND ERYTYROCYTEATE ATPase ACTIVITY AND ERYTHROCYTIC IONIC CONCENTRATION IN PATIENTS WITH ESSENTIAL HYPERTENSION

通过观察６６例高血压病（ＥＨ）病人红细胞变形能力（ＥＤ）和红细胞ＡＴＰ酶活性，细胞内离子浓度变化及其相互关系。结果显示，ＥＨ病人红细胞滤过指数（ＩＦ）较对照组明显增高（Ｐ＜０．００１），红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性、细胞内Ｋ＋，Ｍｇ２＋－浓度明显降低（Ｐ＜０．００１），而细胞内Ｎａ＋，Ｃａ２＋浓度明显增高（Ｐ＜０．００１），且随着ＥＨ病程进展而逐渐明显（Ｐ＜０．００１）。ＥＨ病人红细胞ＩＦ与红细胞Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性及Ｋ＋，Ｍｇ２＋浓度呈明显负相关（Ｐ＜０．００１），与Ｃａ２＋，Ｎａ＋浓度呈正相关（Ｐ＜０．００１）。结果提示ＥＨ病ＨＥＤ降低与红细胞膜ＡＴＰ酶活性降低及离子浓度异常有关。

The erythrocyte deformability(ED)and erythrocyte adenosine triphosphatase(AT-Pase)activity as well as intraerythrocytic ionic concentration were observed in patients with essential hypertension(EH).The erythrocyte filtration index(IF)was significantly higher in EH patients than those in the controls(P<0.001).The activities of Na+-K+- ATPase,Ca2+-Mg2+-ATPase and the intraerythrocytic K+,Mg2+ concentration were all significantly lower than those in the controls(P<0.001),but the intraerythrocytic Ca2+,Na+ concentration were significantly higher(P<0.001).These variations in EH patients became more obvious with the development of EH. In the EH group the erythrocyte IF was negatively correlated with Na+- ATPase,Ca2+-Mg2+-ATPase activities and the intraerythrocytic K+,Mg2+ concentration,but there was a positive correlation between the IF and Ca2+,Na+ concentrations.These results indicate that decrease of ED in EH patients is related to the decrease in the erythrocyte ATPase activity and the changes in the intraerythrocytic ionic concentration.