子宫肌瘤组织内性激素受体免疫组化检测

DETECTION OF SEX HORMONES RECEPTORS IN UTERINE LEIOMYOMA USING IMMUNOHISTOCHEMICAL TECHNIQUE

采用免疫组化ＰＡＰ法对４４例子宫平滑肌瘤和相应正常子宫肌层组织内的雌、激素受体（ＥＲ）和孕激素受体（ＰＲ）进行了检测。结果表明，子宫肌瘤及相应子宫肌层组织均含有ＥＲ和ＰＲ；肌瘤组织、子宫肌组织ＥＲ和ＰＲ的阳性率之间均有显著性差别（Ｐ＜０．０５），肌瘤组织内ＥＲ和ＰＲ含量均高于正常肌层组织。同时测定了２０例血清雌二醇和孕酮含量，其含量在增殖期与正常参考值间差别有显著性，分泌期差别无意义。ＥＲ和ＰＲ阳性率与年龄分组无关。初步探讨了其与子宫肌瘤发生、生长的关系及采用孕激素治疗子宫肌瘤的可能性。

The contents of estogen and progesterone receptors(ER and PR)in leiomyoma and the corresponding myometrium were determined in 44 women by the immunoperoxidase antiperoxidase method.The results showed that leiomyoma and the corresponding myometrium both contained ER and PR,but the levels in the former were significantly higher than those in the latter.The ER and PR levels were higher in the proliferative phase than in the secretory phase.The serum contents of estradiol(E2)and progesterone(P) measured in 20 of the patients were found to be identical.These results were used to explore the relationship between the sex hormone receptor and the genesis and growth of uterine myoma.They may provide useful information in the clinical management of this desease by the P therapy.