406株淋病奈瑟氏菌对青霉素G敏感度的测定

SENSITIVITY OF 406 NEISSERIA GONORRHOEA STRAINS TO PENICILLIN

对青岛地区流行的４０６株淋病奈瑟氏菌进行青霉素最小抑菌浓度的测定（ＭＩＣ）。结果，对青霉素Ｇ高度敏感者（ＭＩＣ＜０．０６ｍｇ／Ｌ）９９株，占２４．５％；中度敏感（ＭＩＣ在０．１２５～０．５ｍｇ／Ｌ）２３８株，占５８．５％；总敏感率为８３．０％。耐药（ＭＩＣ≥１ｍｇ／Ｌ）者６９株，占１７．０％；在耐药菌株中有２３株ＭＩＣ≥１６ｍｇ／Ｌ，且这２３株耐药菌的β－内酰胺酶试验均为阳性。表明耐青霉素株在青岛地区流行的淋病奈瑟氏菌中占有较大比例，应予以重视。

The sensitivity to penicillin of 406 Neisseria gonorrhoea strains isolated from patients in the district of Qingdao was determined. 99 strains were found to have an MIC of 0. 06mg/L(24.5%)and 238 strains an MIC of 0.125～0. 5mg/L(58.5%). The total rate of sensitivity was 83%. Another 69 strains were drug-resistant with an MIC≥1. 0mg/L, of which 23 showed an MIC≥16mg/L and were allβ-lactamase producers.The above indicates that a large proportion of Neisseria gonorrhoea prevailing in the district of Qingdao is resistant to penicillin,which should be taken seriously.