摘要
应用５种不同浓度溴隐亭溶液与离体精液混合孵育，观察其对体外精子受精功能的影响。结果表明，浓度为１０ｍｍｏｌ／Ｌ的溴隐亭溶液可明显抑制精子的存活率和其对宫颈粘液的穿透能力，与对照组相比差异有极显著性意义（Ｐ＜０．０１）；而其它４种浓度的溴隐亭溶液对精子功能的影响差异无显著性（Ｐ＞０．０５）。提示经阴道应用溴隐亭治疗高泌乳素血症引起的女性不育症时，小剂量用药对精子功能并无明显干扰。
In vitro semens was incubated in bromocriptine solutions of six different densities to observe the effects on the fertilizing capability of the sperm. The results revealed that only a bromocriptine solution of 10mmol/L can significantly inhibit the survival rate of the sperm and its power of penetrating through the cervical mucus,showing significant differences from the control group. The other five concentrations(5.0,2.5,1.0,0.5 and 0.1) showed no effects on the sperm's functions. This suggests that a low doze of bromocriptine used by vagina for the treatment of hyperprolactin does not interfere with the fertilizing abilities of the sperm.
出处
《青岛医学院学报》
1994年第3期220-222,共3页
Acta Academiae Medicinae Qingdao Universitatis
