消化道癌肿病人血清CA－50与CEA的对比研究

VALUE OF DETECTION OF CA-50 AND CEA IN SERUM OF PATIENTS WITH CARCINOMA OF DIGESTIVE SYSTEM

用免疫放射技术（ＩＲＭＡ）对１２７例消化道癌肿病人与５２例正常对照组血清ＣＡ－５０进行检测，同时对９４例消化道癌肿病人及４０例正常对照组血清癌胚抗原（ＣＥＡ）进行放射免疫测定（ＲＩＡ），对ＣＡ－５０与ＣＥＡ的诊断价值进行了比较。结果表明，胰腺癌、壶腹癌、肝癌、胃癌、大肠癌的血清ＣＡ－５０均较对照组明显升高，差异均有显著性意义（Ｐ＜０．０１～０．０５），肝癌血清ＣＥＡ较对照组无显著升高（Ｐ＞０．０５）。ＣＡ－５０的ＩＲＭＡ的灵敏度较ＣＥＡ的ＲＩＡ明显升高，差异有显著性（Ｐ＜０．０５）。提示ＣＡ－５０的ＩＲＭＡ对消化道癌肿的诊断和鉴别有一定意义，其灵敏度优于ＣＥＡ的ＲＩＡ．

Serum CA-50 was measured in 127 patients with carcinoma of the digestive system and in 52 healthy controls by immunoradiomatric assay(IRMA).Serum CEA was measured in another 94 patients with carcinoma of the digestive system and 40 normal controls by radioimmunoassay(RIA).It was found that the serum CA-50 levels in patients with carcinoma of the pancreas,ampulla, liver, stomach or colon were significantly higher than those in the controls(P<0.01～0. 05), but the difference in serum CEA concentration between patients with carcinoma of the liver and the controls had no statistical significance(P>0.05). CA-50 IRMA showed a significantly higher sensitivity than CEA RIA (P<0.05).We concluded that the dectction of CA-50 by means of IRMA is helpful to the disgnosis and differentiation of carcinoma of the digestive system.