摘要
应用Ｘ染色体长臂末端Ｓｔ１４－１（ＤＸＳ５２）多态探针对一个Ｆｒａ（Ｘ）家系进行限制性片断长度多态（ＲＦＬＰｓ）分析，在分析的１２名成员中，该探针显示了良好的多态性，与Ｆｒａ（Ｘ）位点的重组率为１４．３％。通过ＲＦＬＰｓ检测结合Ｂａｙｅｓ分析，新确定２例携带者，２例风险提高，３人排除携带者，为女性成员的生育提供了再发风险依据。
A high polymorphic Xq28 DNA probe St14 (DXS52) was used in restrict fragment length Polymorphism ( RFLP) analysis in a large Fra (X)family, in which 12 individuals showed polymorphism in the locus. A recombination between Fra (X) site and St14 was estimated about 14.3%. Based on the RFLP and Bayes analysis, we could ascertain the carrier status in 7 Possible carriers, in whom, 2 were carriers, 2 raised risk from 25% up to 45.25% and 3 had risk less than 10%.
出处
《山东医科大学学报》
1994年第1期20-22,共3页
Acta Academiae Medicinae Shandong
