摘要
对异搏停、汉防己甲素及硝苯吡啶３种钙通道阻滞剂（ＣＣＢ）分别增强Ｋ５６２细胞对足叶乙甙（ＶＰ１６～２１３）、阿霉素、三尖杉酯碱及长春新碱（ＶＣＲ）等４种化疗药物的敏感性进行比较研究，同时研究异搏停、汉防己甲素对耐药Ｋ５６２细胞（Ｋ５６２／ＶＰ１６细胞）对上述药物毒性增强作用。结果提示汉防己甲素作用最优，其次为异搏停，两者对Ｋ５６２／ＶＰ１６细胞毒性增强作用大于ＶＰ１６敏感的Ｋ５６２细胞。ＣＣＢ的抗耐药性作用在一定范围内的药物浓度中以及耐药白血病细胞中作用显著。ＣＣＢ与化疗药物合用表现一定程度毒性作用，但与两者单用的毒性改变相似，因此认为ＣＣＢ在增强化疗药物作用中有一定临床应用价值。
e have compared effect of three kinds of calcium-channel-bleckers(Tetrandrine,Varapamil , Nifedipine)seperately on enchancing the sensitivity of the human K562erythroleukemia to fiur antineoplastic drugs (Adriamycin , VP16 , Harrintoning , Vincristine)andthe effect of Tetrandrine ,Varapamil on enchancing the sensitivity of K562/VP16 to VP16. Theresult indicates that tetrandrine and varapamil can greatly enhance thd sensitivity of K562,especially the sensitivity of K562/VP16. Terandrine is more effective than varapamil. Thesynerggetic effect CCB and antineoplastic drugs can cause the cardiacside effect in somedegree,but the side-effect in some degree ,bu+the side-efecf is not much stronger than that of CCBand anrineoplastic drugs respertively, So, CCB can be considered to have some value in clinicalapplication.
