摘要
采用亚硝酸盐法测定３０例正常人和５０例急性白血病患者血清ＳＯＤ活力变化，结果正常人ＳＯＤ总活力９４．４３±１４．５６Ｎｕ／ｍｌ，Ｍｎ－ＳＯＤ／Ｃｕ·Ｚｎ－ＳＯＤ比值０．５３±０．１６。初分析，急性白血病患者ＳＯＤ总活力７９．７９±２９．７６Ｎｕ／ｍｌ，比正常人明显下降（Ｐ＜０．０５），而Ｍｎ－ＳＯＤ／Ｃｕ·Ｚｎ－ＳＯＤ比值则较正常人明显升高（Ｐ＜０．０１），缓解期患者ＳＯＤ总活力和Ｍｎ－ＳＯＤ／Ｃｕ·Ｚｎ－ＳＯＤ比值分别为９１．５４±２１．５２Ｎｕ／ｍｌ和０．４６±０．２９均接近正常水平（Ｐ＞０．０５）。在综合分析各种ＳＯＤ活力的基础上，表明白血病患者血清ＳＯＤ变化与疾病的发生和发展有关。
The nitrite method was used to assay the superoxide dismutase(SOD)activity in 50 casesof acute leukemia and 30 normal controls.The mean concentration of serum SOD in the earlystage group was 79. 79±29. 76 Nu/ml and was significantly decreased(P<0. 05)as comparedwith normal subjects(94. 43±14. 56Nu/ml).The ratio of Mn-SOD to Cu·Zn-SOD in theearly stage group was 1. 92±2. 60 and was significantly increased(P<0. 01)as compared withnormal subjects(0. 53±0.16).The mean concentration of serum SOD and the ratio of Mn-SOD to Cu·Zn-SOD in the remission period group were 91. 54±2l. 52 Nu/ml and 0. 46±0. 29 respectively , and recovered normal level(P>0.05).These resultssuggested that the serumSOD activities in acute leukemia were closely related to the change of the disease.
