对甲苯磺酸/甲醇试剂用于气相色谱法中羧酸甲酯的衍生化反应

THE DERIVATIVE REAGENT OF ESTERIFICATION REACTION WITH p-TOLUENE SULFONIC ACID/METHANOL IN GAS CHROMATOGRAPHY

羧酸和甲醇在酸的催化下进行酯化反应,是气相色谱衍生化反应的常见方法。常用方法有CH_3OH～HCl法,CH_3OH_3OH—H_2SO_4法,CH_3OH—BF_3法,这些方法都比较成熟,在实际应用中也各具特点。曾有人用对甲苯磺酸(P—TSA)作为羧酸酯化反应的催化剂,该法对一些复杂的有机酸和醇反应转化率较高,并有不少这方面的合成专利和报导。本文探讨将PTSA—CH_3OH法用于色谱分析的新的甲酯化方法。采用某些有机酸和甲醇反应,考察P—TSA的催化效能,实验结果表明:P—TSA对三类羧酸的甲酯化反应都有较好的催化效果,尤其苯甲酸、水杨酸、邻氯苯甲酸等芳香酸用CH_3OH—PTSA法优于CH_3OH—HCl,CH_3OH—BF_3法。

This paper, esterification of some carboxylic acid with PTSA/CH_3OH has been studied. Fatty acids, aromatic carboxylic acid and dicarboxylicacid can be esterified by PTSA/CH_3OH. The estes may be prepared directly by GC. Results show that PTSA is the better catalyst than such as hydrogen chloride, borontrifluoride.