摘要
将３２只新西兰种幼兔随机分为对照组、室息组、窒息＋ＳＯＤ组。各组均于实验开始后２４小时心脏取血查ＬＰＯ、ＳＯＤ和ＧＳＨ－Ｐｘ、并取脑组织测脑水分含量。窒息组与对照组比较，血清ＬＰＯ、脑水分含量明显增高、（Ｐ均＜０．０１），血中ＳＯＤ、ＧＳＨ－ＰＸ活性明显降低（Ｐ均＜０．０１），窒息组ＬＰＯ与脑水分含量呈正相关关系。室息＋ＳＯＤ组与室息组比较，血清ＬＰＯ、脑水分含量明显减少（Ｐ均＜０．０１），ＧＳＨ－Ｐｘ活性增高（Ｐ＜０．０１）。提示ＯＦＲ参与了窒息所致脑损伤的病理过程，外源性ＳＯＤ可对室息幼兔脑组织起保护作用。
hirty two young rabbits were divided into three
groups: control ,asphyxial and asphyxiad + SOD,Blood was drawn from
the hearts ofthese groups after 24hours,Oxygen free radical(OFR) in
the bloodwas measured and H2O of the cerebral tissue was
determined,Comparedwith the control group, LPO of the serum and H2
Oof the cerebral tis- sus significantly increased in the asphyxial
group, while SODandGSH- px of the blood decreased significantly. And
serum LPO was positivecorrelation with H2O of cerebral tissue in
the asphyxial group,Com- pared with the asphyxiai group,serum LPO and
H2O of the cerebral tissursignificantly decreased in the asphyxial +
SOD group. while GSHPx sign- ificantly increased. The results of the
experiment suggested that OFRcaused the brain to damage because of
acute asphyxial and foreign SODeffectively protected the brain
tissue of asphyxial young rabbits.
关键词
窒息
脑损伤
氧
自由基
超氧化物歧化酶
asphyxial
brain damage
oxygen free radical
superoxidedismutase
