TXA_2，PGI_2失调对大鼠急性胰腺炎血循环的影响

Effects of Thromboxane A_2 and Prostacyclin Imbalance On Pancreatic Circulation in Acute Pancreatitis in Rats

应用牛磺胆酸钠诱发大鼠急性胰腺炎模型，观察外源性ＰＧＩ２和血栓素Ａ２合成酶抑制剂Ｄａｚｍｅｇｒｅｌ对大鼠急性胰腺炎胰腺血流量、血小板聚集率、胰腺组织病理形态及大鼠存活率的影响。结果表明：ＰＧＩ２或Ｄａｚｍｅｇｒｅｌ一定程度上提高了急性胰腺炎胰腺血流量和单位组织灌注量，血小板聚集率降低，血浆ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值下降；联合应用ＰＧＩ２、Ｄａｚｍｅｇｒｅｌ，血浆ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值、胰腺血流量、灌注量及血小板聚集率与假手术组接近（Ｐ＞０．０５），胰腺病理形态损害显著减轻，死亡率降至２６．７％。提示血栓素Ａ２、前列环素失平衡与胰腺血液循环紊乱有关，而参与大鼠急性胰腺炎发病。

The effects of exogenous PGI2 and dazmegrel, a selective thrombaxane A2 synthetase inhibitor,on the changes of pancreatic blood flow were studied in experimental rat acute pancreatits by injection of sodium tarocholate into the pancreatic duct.Results showed that the pancreatic blood flow,pancreatic tissue perfusion,platelet aggregation rate as well as the pancreatic pathology were only somewhat improved when either PGI2 ordazmegrel alone was used.Combination treatment with both agents,howerver,produced much pronounced improvements:The pancreatic circulation and pancreatic tissue perfusion were much increased,the platelet aggregation rate and the ratio of TXB2/6-keto -PGI1α were significantly reduced,and the survival time greatly prolonged vs the untreated rats, but not significantly different from those in the sham operation group(P>0.05).These suggested the imbalance between TXA2 and prostacyclin might be related to the disturbance of microcirulation in the pancreas in acute pancreatitis of rats.