脑益嗪对大鼠肝纤维化肝透明质酸、羟脯氨酸及N－乙酰－β－氨基葡萄糖苷酶活性的影响

Effects of Cinnarizine on Hepatic Hyaluronic Acid,Hydroxyproline Contens and N-Acetyl-β-Glucosaminidase Activities in Experimental Rat Hepatic Fibrosis

用四氯化碳（ＣＣＬ４）造成大鼠肝纤维化，发现钙拮抗剂Ｃｉｎ能明显降低大、中剂量早期治疗组和大剂量晚期治疗组肝ＨＡ含量（Ｐ＜０．０１）；大剂量Ｃｉｎ使早期治疗组肝Ｈｙｐ含量降低（Ｐ＜０．０５），晚期治疗组肝总β－ＮＡＧ活性下降。实验提示，Ｃｉｎ在某些生化指标上反映出对肝纤维化有一定防治效果，尤其在肝纤维化的早期，应用Ｃｉｎ可望获得延缓或阻止肝纤维化发展的作用。

In high or median dosage,Cinnarizine significantly decreased the hepatic hyaluronic and content(P<0.01) in rats with CCL4-induced hepatic fibrosis in an early stage;in high dosage, it did so even in advanced stage.In high dosage,the same agent de creased significantly the hydroxyproline content(P<0.05) in early stage,and also the hepatic total N-acetyl-β-glucosaminidase activities (P<0.01) in advanced stage.The experiments suggested cinnarizine has preventive and therapeutic effects on hepatic of rats,especially in early stage of the disease.