摘要
报告９４例胃癌癌胚抗原的免疫组化研究，其中４５例既做免疫组化同时又作术前血清癌胚抗原检测，并对２１例胃癌病人作了随访。结果提示早期胃癌的５年生存率为８３．３％（５／６）；晚期胃癌的５年存活率为３３．３％（１／１５）；血清癌胚抗原浓度轻度升高或组织内癌胚抗原染色为（－）或（＋）时有较好的预后。而当血清癌胚抗原浓度明显升高＞８０ｇ／ｍｌ或组织内癌胚抗原表达为强阳性（＋＋）特别是（＋＋＋）时其术后存活率明显降低。而且通过２种方法的比较研究，癌胚抗原免疫组化显色方法比血清癌胚抗原检测更显敏感，Ｐ＜０．０１，可作为推测胃癌预后的１项指标。
Carcinoembryonic antigen(CEA)was assayed immunohistochemically in 94 cases of surgically resected gastric carcinoma. Among them serum CEA determination was also carried out in 45 cases. Followup data in 21 cases showed a 5-year survival rate of 83.3% in early cases while 33.3% in advanced cases. Slight elevation of the serum CEA level or a negtive or a weakly positive immunohistochemical CEA reaction was usuaully associated with a better prognosis. A high level of serum CEA>80 ng/ml or a strong tissue CEA positivity suggested a low postoperetive survival. By comparison, the immunohistochemical assay appeared more sensitive than the serum determination (P<0.01),and may serve as a reliable index of prognosis after surgery.
出处
《上海第二医科大学学报》
CSCD
1994年第2期93-97,共5页
Acta Universitatis Medicinalis Secondae Shanghai
