几种营养素和硒、锗对胃癌细胞增殖的影响

Effects of Selenium,β-Carotene,Vitamin C, Vitamin B_(12)and Ge-132 on Human Gastric Cancer Cell Proliferation

本文研究了硒、β－胡罗卜素、维生素Ｃ、维生素Ｂ１２４种营养素和有机锗（Ｇｅ－１３２）对人类胃癌细胞（ＳＧＣ－７９０１）增殖的影响。结果提示硒对该细胞的增殖有双向作用，浓度高于１０μｍｏｌ／Ｌ抑制细胞生长，低于该浓度则刺激细胞生长。β－胡罗卜素浓度在１０－４ｍｏｌ／Ｌ～１０－８ｍｏｌ／Ｌ范围内对该细胞生长有明显的抑制作用。有机锗（Ｇｅ－１３２）对胃癌细胞的生长无明显的抑制作用。维生素Ｃ在１０－４～１０－８ｍｏｌ／Ｌ浓度范围内对该细胞生长有明显的抑制作用。维生素Ｂ１２在１～５００μｇ／ｍｌ浓度范围内对该细胞生长也有明显的抑制作用。上述结果表明硒、β－胡罗卜素、维生素Ｃ、维生素Ｂ１２对胃癌的防治可能是有益的。

The study was conducted in vitro with human gastric cancer cell line (SGC7901) to determine the effeccts of selenium ,β-carotene,vitamin C,vitamine B12 and Ge-132 on cell proliferation and cellular protein content.Selenium as sodium secenite showed a phasic effect on cancer cell proliferation,ie, a lower concentration of selenium (<10 μm)stinulated the cell growth while a higher one (>10μm) suppressed the cell growth in a dose-dependent manner.β-Carotene, vitamin C and vitamin B12 all inhibited cancer cell growth significantly.While G-132 had no effects on cancer cell growth .These results suggested that a proper use of the nutrients might be beneficial in the prevention of and mingt act as an adjuvant treatment of human gastric cancer.