银屑病患者血液流变学变化

Hemorrheological Changes in Psoriatic Patients

对３１例寻常型银屑病患者，２５名正常健康者，进行了系统的血液流变学观察。结果银屑病组全血粘度在高切变率及低切变率时皆显著高于健康对照组，血浆粘度的增高尤为显著。银屑病组中尚有９例（２９．０％）体外血栓试验Ｑ值增高，及４例（１２．９％）血小板聚集增强。其它如红细胞压积、ＴＫ值、血沉及血沉方程式Ｋ值、纤维蛋白原等指标两组间均无明显差别。结果提示红细胞聚集能力的增强和血清内大分子物质的增加可能是使血粘度增高的因素，血小板聚集功能、血栓形成及红细胞内粘度的变化也值得进一步研究，以便更合理地应用活血化瘀的治则来治疗本病。

Thirty-one cases of psoriasis vulgaris and 25 healthy individuals as controls were investigated for the changes of hemorrhological parameters.Results indicated that the whole blood viscosity levels in psoriatics were significantly higher as compared with normal controls both at 230 S-1 and 11.5S-1,and the plasma viscosity levles in psoriatics were significantly higher than in controls,29% of psoriatics showed increased Q value (thrombosis test in vitro), and 12.9% increase of platelet aggregation.Other parameters such as hematocrit, TK value, ESR and K value, and fibrongen were compared without significant differences vs the control.An increase of erythrocyte aggregation and large molecular substances in serum might be the possible cause of the high blood viscosity in psoriasis.Furhter investigation of platelet aggregation,thrombosis and intermal viscosity of the red cell would be needed .To elucidate the mechanism of hemorrheological changes in psoriasis may be helpful to conduct a reasonable remedy of activating the blood circulation and dissolving the stasis according to the principles of Chinese traditional medicine.