高血压和急性脑卒中患者PA抗原和血小板活化程度的测定意义

Significance of Measurement of Plasminogen Activators (PAs) Antigen Concentration in Plasma and Evaluation of Platelet Activation in vivo in Hypertension and Acute Ischemic Cerebral Apoplexy

对１３名高龄正常人、１２例高血压和１６例急性缺血性脑卒中患者同时测定了血浆ｔ－ＰＡ、ｕ－ＰＡ、βＴＧ和ＰＦ４４种指标。与年龄较轻的正常人比较，高龄者４种指标测定值均显著增高（Ｐ＜０．０５～０．００１）；与高龄者的测定值作比较，高血压患者βＴＧ和ＰＦ４明显较高（Ｐ＜０．００１），ｔ－ＰＡ和ｕ－ＰＡ无显著差异，但急性缺血性脑卒中患者的ｔ－ＰＡ抗原血浆水平有明显降低（Ｐ＜０．００１～０．０１）。根据结果，分析了这些变化的可能机制和同时测定这４种指标的临床意义。

Four hemostatic molecular markers, the tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA),β-thromboglobulin (βTG) and platelet factor 4 (PF4), were determined in 13 elderly normal subjects, 12 cases of hypertension and 16 cases of acute ischemic cerebral apoplexy (AICA). Compared with normal values taken from yourger subjects,the plasma levels of all the 4 markers in the elderly were significantly elevated (P<0.001).The average values of βTG and PF4 in patients with hypertension were higher than those in elderly control(P<0.001),while no significant differences were found on t-PA and u-PA plasma levels between the 2 groups.Higher βTGand PF4 levels were also found in cases of AICA, whereas the t-PA plasma level was significantly lower than that in elderly control or cases of hypertension (P<0.001-0.01). The mechanism of the variations in plasma levels of the 4 markers and the clinical significance of their mesurement were discussed.