β─内啡肽对正常人红细胞免疫功能的调控实验研究

A LABORATORY STUDY ON THE EFFECT OF β─ENDORPHIN ON HEALTHY RBC IMMUNE FUNCTION

以健康人红细胞Ｃ３ｂ受体花环率为指标，观察不同浓度β─内啡肽对红细胞免疫功能影响。结果发现，低浓度时对红细胞免疫功能起促进作用，高浓度时则起抑制作用。加入一定浓度的纳洛酮后可以阻断β─内啡肽的作用，并对其机理及意义进行了讨论。

To investigate the role of β─endorphin in the regulation of RBC immune function,the effect of β─endorphin on healthy RBC c3b receptor rosette-forming rate(RC3bRR) was studied in vitro. It was found that Pendorphin at 10￣(-6)～10￣(-5)mol/L could depress RC3bRR,while at 10￣(-8)～10￣(-7) mol/L could enhance RC3bRR. The regulating effect of β-endor phin on RC3bRR was blocked by naloxone. Our results indicated that β-endorphin could regulate RBC immune function and this action may be mediated by opioid receptor.