病毒性心肌炎患者多项免疫参数分析

ANALYSIS OF IMMUNOLOGICAL PARAMETERS OF VIRAL MYOCARDITIS

本文对比检测急性期与恢复期病毒性心肌炎患者多项免疫指标，结果揭示急性期病毒性心肌炎患者中性粒血胞的吞噬和杀菌功能明显低下，而恢复期患者的中性粒细胞功能基本恢复至正常人水平。急性期和恢复期病人的ＮＫ细胞活性明显低于健康人，尤以急性期下降更为明显。不同期患者的外周血中Ｔ和Ｂ淋巴细胞百分率则无异常变化，与健康人组近似。患者静息或诱导后表达ｍＩＬ—２Ｒ的活化Ｔ淋巴细胞数明显高于健康人组，而血中ＳＩＬ—２Ｒ水平与正常值近似。此外，两组患者ＩｇＧ、Ａ、Ｍ水平均有不同程度的明显升高，在恢复初期仍保持较高的ＩｇＭ水平。上述结果揭示急性期病毒性心肌炎患者中性粒细胞和ＮＫ细胞活性下降、三种Ｉｇ升高，确有免疫水平异常现象，但与疾病的因果关系有待探讨。

The immunological parameters of acute and convalescent viral myocarditis were studied.The results showed that the phagocytic and anti-bacterial function of neutrophils decrased significantly in acute viral myocarditis and returned to normal in convalescence stage. The activity of NK cells decreased markedly in both acute and convalescent viral myocarditis, especially in acute stage. The percentages of T and B cells were not different from normal in both acute and convalescent viral tuyocarditis. The active T lymphocytes that express mIL2R increased significantly and the blood mIL-2R level was within normal range. IgA and IgM increased significantly in both acute and convalescence stages of viral myocarditis andIgM remained higher in early convalescence stage.