进展期贲门癌患者脾脏免疫状态的研究

STUDIES ON SPLEEN IMMUNE STATUS IN THE PATIENTS WITH ADVANCED CARDIAC CANCER

为了探讨进展期贲门癌患者脾脏的免疫状态，分别检测了７０例患者的外周血、脾静脉血与脾脏的ＮＫ细胞活性及Ｔ－淋巴细胞亚群。结果显示：（１）与正常人外周血淋巴细胞（ＰＢＬ）相比，进展期贲门癌患者的ＰＢＬ，脾静脉血淋巴细胞（ＳＶＬ）及脾细胞（ＳＣ）的ＮＫ细胞活性、ＣＤ３＋、ＣＤ４＋细胞降低，ＣＤ８＋细胞增多，致ＣＤ４＋／ＣＤ８＋细胞比值明显下降；（２）从进展期贲门癌患者ＰＢＬ、ＳＶＬ与ＳＣ三者之间比较结果可见，后二者的ＮＫ细胞活性、ＣＤ４＋／ＣＤ８＋细胞比值均明显低于ＰＢＬ。作者认为，进展期贲门癌能削弱患者的整体免疫功能；随着肿瘤的进展，脾脏不但未能起正性免疫作用。且逐步转向负性免疫状态。

In order to study the spleen immune status in the patients suffered from advancedcardiac cancer,the authors have evaluated the activity of natural killer(NK) cells andsome T-lymphocyte subgroups in periphcral blood (PBL),splenic venous blood(SVL),and splenic cells(SC)of 20 cases,The results skowed that(1)In comparison withnormal PBL of healthy persons,these patients showed a lower NK cell activity,depressed CD3+ and CD4+ cell count and increased CD8+ cell count,resulting in a decrease ofCD4+/CD8+ ratio;and(2)In these patients,the NK cell activity and CD4+/ CD8+ ratioin SVL and SC were signi ficantly lower than that in PBL.The authors concluded thatthe advanced card iac cancer may weaken the patients whole immunity.With the develop-ment of tumor, the spleen is turned to play a negative rather than a positive role inimmunity.