三苯氧胺治疗子宫内膜癌作用机理的探讨

THE STUDY ON THE MECHANISM OF TAMOXIFEN TREATMENT OF ENDOMETRIAL CARCINOMA

本研究应用辣根过氧化物酶标记的雌二醇、孕酮的组织化学方法（简称酶联组化法）检测１６例经病理组织学证实为子宫内膜癌癌组织雌、孕激素受体，观察经三苯氧胺２０ｍｇ每日三次口服１０天治疗前后受体含量及病理组织学的改变，发现治疗前：子宫内膜癌组织雌激素受体阳性率为５６．２５％，孕激素受体阳性率为３７．５％，治疗后：雌激素受体阳性率为６２．５％，孕激素受体阳性率为６８．７５％，１６例中有３例病理组织学检查仅见混合型增生过长或增生期子宫内膜，另外６例组织学分级有好转。本研究结果提示：三苯氧胺治疗子宫内膜癌有一定效果，其作用机理可能为直接作用于肿瘤组织，或通过孕激素受体的增加而使肿瘤组织的生长受抑制。

16 cases of endometrial carcinoma documented pathologically treated by tamoxifenwere presented in this paper.ER and PR of the tumor tissue were examined,the patho-logical change were observed.After treatment,the positive rate of ER was 62.5%,higher than that before treatment(56.25%).The positive rate of PR was 68.75%,higher than that before treatment(37.5%).The pathological change after treatment:3 cases mixed hyperplasia of endometrium and proliferative phase;6 cases the histolo-gical grade improved. Therefore tamoxifen is effective in treatment of endometrial car-cinoma.Its role of action may be directly influence the tumor tissue and increase thecontents of PR.