500例合格献血员丙型肝炎病毒感染的危险因素分析

RISK FACTOR ANALYSIS OF HCV INFECTION AMONG 500 ELIGIBLE PLASMAPHETESIS DONORS

对河南新乡市５００例ＨＢｓＡｇ、抗－ＨＢｃ（乙型肝炎核心抗体）筛检阴性的单采浆还输血球的合格献血员丙型肝炎病毒（ＨＣＶ）感染的危险因素进行单因素和多因素的分析。结果表明：献血时间、既往和本次谷丙转氨酶（ＡＬＴ）异常及静脉内注射史，在Ｌｏｇｉｓｔｉｅ回归模型的多因素分析中具有重要意义。献血次数、不同地区及血型也是不容忽视的危险因素（Ｐ＜０．０１）。调查中发现献血员中丙型肝炎抗体（抗－ＨＣＶ）感染率为２１．０％，说明单采浆还输血球献血员为ＨＣＶ感染的高危人群。值得注意的是首次献血员的ＨＣＶ感染率为１０．３％，提示该地区呈ＨＣＶ地方性流行状态。未发现性别、年龄、职业、婚姻、家庭人口数同感染ＨＣＶ有关。

Risk factors for hepatitis C virus infection were analysed by the Chi-square test and multiple logistic regression statistics in 500 eligible plasmaphetesis donors from Xin-Xiang eity, Henan province in 1992.The results showed that time of blood donation, history of abnormal liver disfunction(ALT), the history of intravenous injections were of great signifieance in the logistic regression model. The number of repeated plasmaphetesis, variation of geographic areas and the blood type were also relevant risk factors. The infection rate of HCV in the blood donors was 21 .87%. It illustrates the plasmaphetesis donors to be a high risk population group. It is notable that the HCV infection rate reached 10.3% in those first time donors. It seems there is an endemie HCV infection status in the area. In this study there was no relationship between the HCV infection and sex, age, occupation, marital status or number of persons in the household.