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肝胆显象剂-^(99m)Tc-芳甲酰肼羰甲基亚氨二乙酸类的合成和动物实验

SYNTHESIS OF ^(99m)Tc-AROYLHYDRAZINOCARBONYLMETHYLIMINODIACETIC ACIDS AND THEIR ANLMAL STUDY, HEPATOBILIARY PHARMACEUTICALS
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摘要 合成9个新类型芳甲酰肼羰甲基亚氨二乙酸衍生物,用氯化亚锡还原高锝酸钠制得99mTc-标记化合物,用小白鼠和家兔实验的结果,都显示不同程度为肝脏细胞吸收,血中清除和分泌于胆道。其中以99mTc-2-甲氧基-5-溴苯甲酰肼羰甲基亚氨二乙酸的特异性较好。 Based on the structure specificity of a new comPund isonicotinoylhydrazinocarbonylmethyliminodiacetic acid,nine similar derivatives were synthesized by esterification of aromatic acids,followed by hydrazinolysis, and acylation with nitrilotriacetic acid.The 99mTc-complexes of these compounds were prepared by stannous chloride reduction of sodium pertechnetate in aqueous solution at Ph 6~7. The experimental resuhs in mice and rabbits showed that the 99mTc-complexes all exhlbited varying degrees in the uptake by the liver cells,cleared off from the blood and excreted into the biliary traet.The hepatobiliary specificity of 99mTc-2-methoxy-5-bromobenzoylhydrazinocarbonylmethyliminodiacetic acid was the best among them. It is coneluded preliminarily that the aroylhydrazinocarbonylmethyliminodiacetic acids provide to be a fruitful source for 99mTc-labeled hepatobiliary radiopharmaceuticals.
出处 《上海医科大学学报》 CSCD 1994年第1期60-64,共5页 Journal of Fudan University(Medical Science)
基金 国家自然科学基金
关键词 亚氨二乙酸类 肝胆显象剂 放射药物 aroylhydrazinocarbonylmethyliminodiacetic acids hepatobiliary imaging hepatobiliary radiopharmaceuticals
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二级参考文献3

  • 1薛芬,上海医科大学学报,1987年,14卷,2期,119页
  • 2陈绍亮,上海医科大学学报,1984年,11卷,6期,453页
  • 3周锡瑞,上海医科大学学报,1984年,11卷,4期,247页

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