摘要
用放射免疫法观察了４０例Ⅱ型糖尿病人外周血浆中内皮素的含量及与病程、年龄、空腹血糖（ＦＢＧ）、糖化血红蛋白（ＨｂＡ１）、Ｃ肽、血压的相关关系，并比较了伴和不伴视网膜病变或心脏病变的糖尿病人血浆内皮素水平的不同，其中２０例糖尿病人血浆内皮素含量较年龄、性别匹配的正常对照者明显升高。结果提示：内皮素－Ⅰ可能与糖尿病的慢性血管并发症有密切的联系。
Plasma endothelin-Ⅰ(ET-Ⅰ) concentrations were measured in 40 patients with non-insulin-dependent diabetes mellitus and 20 normal subjects using specific ET-Ⅰ radioimmunoassay. The plasma immunoreactive-endothelin concentrations were found to be greatly raised in patients with diabets(43.6± 22. 1 pmol/L mean ± SEM P<0. 05) and correlated with glucose levels, diastolic pressure diabetic retinopathy and cardiopathy. The elevation of endothelin in diabetic patients may be a marker of and further exacerbate, their vascular disease.
出处
《上海医科大学学报》
CSCD
1994年第6期437-439,共3页
Journal of Fudan University(Medical Science)
关键词
内皮素-Ⅰ
Ⅱ型
糖尿病
血管
并发症
endothelin-Ⅰ
diabetes mellitus
vascular complication
