1991年上海暴发流行病毒性脑炎的病毒学研究

VIROLOGIC STUDY ON AN OUTBREAK OF ECHO 30 VIRUS ENCEPHALITIS IN SHANGHAI,1991

１９９１年６～８月上海暴发流行病毒性脑炎，我院２７８例患儿．分离到４６株ＥＣＨＯ３０型病毒，脑脊液、咽试和粪便标本的ＥＣＨＯ３０型病毒分离率分别是２０％（９／４６）、２５％（７／２８）和８６％（３０／３５）。７６％（６１／８０）患儿恢复期血清ＥＣＨＯ３０型病毒抗体阳性。证实ＥＣＨＯ３０型病毒是脑炎流行的主要病原。抗体动力学研究显示中和抗体产生早，０．５～１月达高峰，３个月无明显下降。本文还探索所分离毒株的细胞敏感性，对热和紫外线抵抗力等生物学特性。

n outbreak of encephalitis occured in Shanghai,during June to August 1991.46strains of ECHO 30 virus were detected in the patients with the isolation rates in dif-ferent specimens:20%(9/46)in cerebralspinal fluid,25%(7/28)in throat swabs and86%(30/35)in feces.76%(61/80)of the patients acquired neutralizing antibody(NTAb)against ECHO 30 isolate in their convalscence sera. These resalts confirtmed thatECHO 30 virus was the main cause of the outbreak of encephalitis. A dynamic study of NT Ab showed that NT Ab appeared early,rose quickly andmaintained more than 3 months. Some biologic characters of the isolates studied wereit’s limited cytopathic spectrum,no pathogenic for suckling mice,negative hemagglutina-tion and rapid inactivity in high temperature and under ultravoilet.