颅脑损伤后脂质过氧化物变化的临床研究

CLINICAL STUDY OF LIPID PEROXIDATION IN TRAUMATIC BRAIN INJURY

作者观察了２０例颅内血肿伤员伤后血清和脑脊液中脂质过氧化物含量的变化，２０例均接受急症手术治疗和大剂量地塞米松治疗（５ｍｇ／ｋｇ）。结果发现，颅脑伤后血清和脑脊液中ＬＰＯ含量明显升高，伤情越重，ＬＰＯ含量升高越明显（Ｐ＜０．０１）；颅脑伤后ＬＰＯ含量与颅内压有关，二者呈正相关（Ｐ＜０．０５）。死亡组４例在手术后第１天血清和脑脊液中ＬＰＯ含量明显高于同等伤情的其他６例伤员；血清中和脑脊液中的ＬＰＯ含量之间的关系也呈正相关关系。本研究结果提示，颅脑损伤后脂质过氧化反应增强，参与了损伤后的继发性脑损害。

he changes of lipid peroxidation(LPO)after traumatic brain injury(TBI)werestudied on 20 cases.All patients suffered from acute intracranial hematoma were opera-ted on and given high-dose dexamethasone(5nm/kg) immrfisyrly after operations. Theresults demonstrated that LPO concentrations both in serum and CSF were significantlyelevated after TBI(P<0.01).The more severe the injury,the higher the LPO Ievel,then the higher the ICP level.At first day after operation,the LPO level of four pa-tients died later was markedly higher than that of other six cases with good recovery,while all of the patients were examinated and earned the same GCS score at admission.We also found that LPO level in serum was closely relevant to that in CSF.These re-sults show that the lipid peroxidation is much activated after TBI,and lipid peroxi-dation may participate in the pathophysiology of TBI.