摘要
本文报道应用有机溶剂和去污剂处理静脉注射免疫球蛋白灭活病毒的结果，用疱疹性口炎病毒作为模型病毒，证明病毒灭活快而有效。经１５分到一小时处理后可杀灭１０７·９－８·７传染剂量的模型病毒。处理后有机溶剂和去污剂残存量极少。病毒灭活处理对静注免疫球蛋白制品无不良影响，制品仍能用于静脉输注。
he results of virus inactivation in intravenous immunoglobulins with organic so-lvent and detergent were described.With vesicular stomatitis virus(VSV)as modelvirus it was shown that such virus inactivation was fast and complete. 107.9-8·7 infec-tious doses of VSV were killed after 15 min to 1 hour treatment.There was only a lit-tle residual solvent and detergent left after treatment. The virus inactivation treatmenthad no adverse effect on properties and quality of the intravenous immunoglobulins,which could be infused intravenously after treatment.
出处
《上海医学》
CAS
CSCD
北大核心
1994年第1期18-21,共4页
Shanghai Medical Journal
关键词
免疫球蛋白
有机溶剂
去污剂
Intravenous immunoglobulin
Solvent/detergent,Virus inactivation
