雅伴对兔脑缺血脑水肿的治疗作用

PROTECTIVE EFFECT OF AVAN ON ISCHEMIC BRAIN EDEMA

本实验利用兔大脑中动脉阻断（ＭＣＡＯ）脑缺血模型，将实验动物随机分成单纯缺血组、缺血前用药及缺血后用药三组。结果发现：单纯缺血组脑组织内Ｈ２Ｏ、Ｎａ＋、Ｃａ２＋含量随缺血时间延长而递增（Ｐ＜０．０１），而Ｋ＋含量则降低；缺血后２４小时两用药组与单纯缺血组相比，Ｈ２Ｏ、Ｎａ＋、Ｃａ２＋含量均降低（Ｐ＜０．０１），Ｋ＋含量则升高。而缺血后用药组变化更明显；两用药组比较，缺血后用药组明显优于缺血前用药组（Ｐ＜０．０１），且缺血后用药组与对照组比较未见显著性差异（Ｐ＞０．０５）．故可以认为雅伴对脑缺血脑水肿有保护作用。

e examined a quinone compound Idebenone (Avan),used as a cerebral metabo-lism activator,for the protective effects on rabbit foal brain ischemia model of cere- bral artery occlusion(MCAO).40 rabbits were randomly divided into 3 groups: simpleischemia,pretreatment and posttreatment groups. Avan suspended in 5% Arabic gumsolution was orally daministered by gavage.In pretreatment group,Avan was in doseof given 40 mg/kg at 1h and 24h before ischemia,In posttreatment group,Avan(80mg/kg)was given 30′ after operation. We measured the Na+,K+,Ca2+and H2O contentsin brain 24h after operation. The difference between treat ment and simple ischemicgroups were singificent (P<0. 01).In both treated groups H2O,Na+,Ca2+ contents weredecreased. Posttreatment group changed even more greater as compared with pretreatmentgroup(P<0.01).These results suggested that Avan has some protective effects on braincdema of focal cerebral ischemia.But its detailed mechanism and discrete effects resu- lted from different timing of medication still remains to be discussed。