摘要
本实验报道结扎大鼠左冠状动脉前降支，造成急性心肌缺血后，血液、部分脑区、垂体及心肌组织中神经降压素免疫活性物质含量显著升高，且并有心肌收缩力减弱、左心室压最大上升速率降低，左心室压峰值下降，血压下降，心力环面积缩小等心功能抑制的变化。提示神经降压素参与急性心肌缺血时心血管反应的调节。
n this study, the anterior descending branch of the left coronary artery was ligatedto produce acute myocardial ischemia in rat. The dynamic changes of immunoreactiveneurotensin (ir-NT)content during ischemia was determined with radioimmuno assay.The results showed that the levels of ir-NT in plasma, some brain areas,pituitary glandand myocardium was markedly increased Meanwhile the left ventricular myocardialcontractility parameters such as dp/dtmax, ventricular systolic pressure, total area offorce loop and blood pressure were markedly decreased. It suggests that the neuroteniintakes a role in the modulatory reaction in acute myocardial ischmia.
出处
《上海医学》
CAS
CSCD
北大核心
1994年第5期266-268,共3页
Shanghai Medical Journal
关键词
神经降压素
心肌缺血
放射免疫测定
Neurotensi
Cardiac function
Radioimmunassay
Myocardial ischemia
