肾脏病抗中性粒细胞胞浆抗体检测的临床意义

The clinical significance of antineutiophil cytoplasmic antibodies in kidney diseases

本文通过分析２６例抗中性粒细胞胞浆抗体（ＡＮＣＡ）阳性肾脏病例的临床病理特点，探讨了ＡＮＣＡ在肾脏病中的临床意义。结果显示，ＡＮＣＡ阳性不仅可见于结节性多动脉炎（４例）、紫癜性肾炎（８例），还可见于Ⅲ型新月体肾炎（２例）及ＩｇＡ肾病（１２例）．ＡＮＣＡ阳性的肾脏病例具有某些共同的临床病理特征，提示可能具有相同的发病机理。ＡＮＣＡ阳性的ＩｇＡ肾病及Ⅲ型新月体肾炎可能是特殊类型的血管炎。

he clinical significance of antineutrophic cytoplasmic antibodies(ANCA)in 26 patients with ANCA associated kidney diseases were in invesgited. The result showed positive serum ANCA may be seen in polyarteritis nedase(4 cases), Henoch-Schonlein nephritis(8 cases) , crescentie nephritis(2 cases)and IgA nephropathy(IgA-N,12 cases). ANCAassociated renal diseases shared some common clinopathological features,which indicated that ANCA partieipated the pahogensis of vasculitides.Both IgA-N and crescentic nephrltis with positive ANCA may be classified as subtypes of vasculitidies.