脂质过氧化引起的DNA损伤研究进展

DNA Damage Induced by Lipid Peroxidation.

脂质过氧化可以引起各种碱基损伤、ＤＮＡ链断裂和各种荧光产物生成，并对ＤＮＡ分子鸟嘌呤碱基具有选择性损伤。过渡金属离子可以明显加深脂质过氧化对ＤＮＡ的损伤程度。多种抗氧化剂、活性氧自由基清除剂对脂质过氧化引起的ＤＮＡ损伤有一定程度的保护作用。具有致突、致癌作用的８－羟基鸟嘌呤已经观察到．脂质过氧化的致突变、致癌变作用机制引起了人们的极大兴趣．

ipid peroxidation may lead to base modifica-tion,DNA strand breaks and formation of var-ious fluorescent products in model systems.bacteria and eucaryotic cells.and the selectivedestruction of the base guanine in DNA.Thetransient metal ions can intensify the DNAdamage obviously.Antioxidants and free radi-cal scavagers have the protective effect of vary-ing degrees for DNA damage induced by lipidperoxidation.8-Hydroxyguanine.which isstrongly implicated in mutagenesis and carcino-genesis. has been observed.The molecularmechanism of mutagenesis and carcinogenesisinduced by lipid peroxidation aroused greatconcerns in the field of free radical biology.