大鼠心肌缺血／再灌及高脂血症的心肌膜损伤

Myocardial Membrane Injury of MyocardlalIscheimia/Reperfusion and Lipoidaema in Rat.

通过大鼠心肌缺血／再灌及高脂血症的模型证实，两者均有明显的生物膜损伤，主要表现为膜磷脂的降低、胆固醇及胆固醇／磷脂比增高、膜脂流动性及膜酶（Ｃａ￣（２＋），Ｍｇ￣（２＋）－ＡＴＰａｓｅ）活性降低。

hrough the experiment model of the myocar-dial ischemia/reperfusion and lipoidaemia inrat, both of them obviously induce membraneinjury: a drop of membrane phospholipids, anincrease in content of free fatty acids, choles-terol and cholesterol/phospholipid ratio, a de-crease in membrane lipids fluidity and activityof membrane enzymes (Ca￣(2+), Mg￣(2+)-ATPase) .These aterations perhaps related to the in-crease of lipids hyperoxidation induced by freeradical and exchange of lipids.