蛋白激酶C研究的最新进展

The Newest Progress of Protein Kinase C.

作为能使蛋白激酶Ｃ（ＰＫＣ）活化的第二信使甘油二酯（ＤＡＧ）不仅可由磷脂酰肌醇（ＰｔｄＩｎｓ）水解产生，大量实验表明还可从磷脂酰胆碱（ＰＣ）水解而来，其中磷脂酶Ｃ（ＰＬＣ）及磷脂酶Ｄ（ＰＬＤ）参与了这一过程，磷脂酶Ａ＿２（ＰＬＡ＿２）的作用产物脂肪酸（ＦＡ）也能激活ＰＫＣ．ＰＫＣ至少有１０种亚型，依据其活化方式可分三大类：典型ＰＫＣ，新ＰＫＣ和非典型ＰＫＣ．ＰＫＣ参与了基因表达的调控．

iacylglycerol (DAG). as the second massen-ger to activate protein kinase C (PKC), maybe derived not only from hydrolysis of phos-phatidylinositol (PtdIns). but also from hy-drolysis of phosphatidylcholine (PC) , in whichphospholipases of the type C and D (PLC andPLD ) participate . Fatty acids (FA), the pro -ducts of phospholipases A2 (PLA2) also acti -vates PKC. PKC has at least 10 subspeciesand 3 group, namely classical PKC, new PKCand atypical PKC. PKC also participates inregulation of gene expression.