血管内皮生长因子与肿瘤

Vascular Endothelial Growth Factor and Tu-mors.

血管内皮生长因子是新近确定的一种具有旁分泌机制的生长因子，能特异作用于血管内皮细胞，促进其增殖及新生血管的形成，同时还有增加血管通透性的作用．由于其生物学活性与实体瘤的生长密切相关，因此对它的研究倍受关注，进展非常迅速．

ascular endothelial growth factor (VEGF)with paracrine mechanism has recently beenidentified . Its growth-promoting activity isspecific for vascular endothelial cells in vitro,VEGF also stimulates angiogenesis and in-creases blood`vessel permeability in vivo. Be-cause its bioactivity has a direct bearing on thegrowth of solid tumors, the researches onVEGF have been payed a good deal of atten-tion and made good progress.