摘要
载脂蛋白J(apoJ)是1990年从人血浆HDL中新分离出的一种酸性糖蛋白,分子量70000,由α及β亚基通过二硫键相连而成.通过apoJcDNA已确定了apoJ427个氨基酸残基的序列.apoJ含双性α螺旋及结合肝素的结构域,可与脂质结合成脂蛋白.apoJmRNA广泛分布于全身各组织,以脑、卵巢、睾丸及肝脏含量最多.apoJ的功能可能有:结合与转运脂质;抑制补体C8及C9的激活;参与精子的成熟等。
polipoprotein J (apo J) has been purifiedfrom human plasma HDL and characterized byde Silva et al in 1990. Apo J is a 70kD glyco-protein, comprised of two disulfide-linked sub-units designated apo Ja (34-36kD) and apo Jβ(36-39kD) . The sequence of the 427 aminoacid residues of apo J was deduced by thecDNA cloning and sequencing. The predicteda helical regions of apo J indicated that three ofthese could generate amphiphilic α helices, andmay be lipid - bind domains in apo J . Apo JmRNA was expressed in relatively high levelsin brain . ovary . testis and liver . Apo J isunique among previous characterized humanapolipoproteins in its structure and tissue dis-tribution. The function of apo J is thought tobe involved in a variety of physiological pro-cesses. including bind and transport lipids.regulation of complement function and spermmaturation etc.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1994年第4期294-299,共6页
Progress In Biochemistry and Biophysics
关键词
载脂蛋白J
结构
功能
apolipoprotein J. apo Jα and apoJβ, apo J HDL, structure and function, apo Jhomologs