米非司酮合并前列腺素终止早孕安全性和有效性的临床随机比较试验

A Clinical Comparative Study on Safety and Efficacy of Mifepristone Combined with PG for Termination of Early Pregnancy

本文９８例停经≤４９天要求终止妊娠的妇女，随机分为三组：Ⅰ、Ⅱ组均口服米非司酮２５ｍｇ，２次／日，连服５次；Ⅲ组一次口服２００ｍｇ第三天上午，Ⅰ组阴道放置ＰＧ０５栓１ｍｇ；Ⅱ、Ⅲ组均口服米索前列醇６００μｇ．完全流产率９６．９％，不全流产率２．０％，１例继续妊娠（１．０％），三组间无显著性差异（Ｐ＞０．０５）。除Ⅰ组有７例腹泻（２４．１％．１％），与Ⅱ、Ⅲ组间有显著性差异（Ｐ＜０．０１）Ⅲ组中１例呕吐严重补液治疗外，药物所致副反应轻微，不需处理。结果提示三种用药方案用于抗早孕，安全、有效率高。本文对三组对象于妊娠终止前后作血清β－ｈＣＧ、Ｅ２．Ｐ，ＰＲＬ及皮质醇测定并进行对比。

Ninety-eight women (amenorrhea<49 days)asking for induced abortion were ramdomly divided into three groups. 25 mg of Mifepristone two times a daily for 5 doses (in group Ⅰ and Ⅱ ) or 200 ma in a single dose (in group Ⅲ ) were orally administered, followed by administration of one suppository of 1 mg of PG 05 (in group Ⅰ) or oral administration of misoprostol 600μg (in group Ⅱ and Ⅲ ) on d3 morning.Comlpete and incomplete abortion rates for these three groups were 96 .9% and 2 .0% respectively, only one case (1 .0%) had continuing live birth. Among these three groups there was no significant difference (P>0.05),In general,the side effects were mild, there were 7 cases (24.1%) with diarrhea in group I, which was significantly different as compared with group Ⅱ and groupⅢ (P<0.01). These resultg suggested that these three regimes are safe, high effective and acceptable for termination of early pregnancy. In this papes, We also studied the serum β-hCGE2,P, PRL and Oortisol level before and after temrinalion of early pregnancy.