用双剂量实验数据分析药物的米氏消除参数的识别问题

On the Identification of Michaelis-Menten Elimination Parameters Based on Two Sets of Dose-Response Data

本文分析了给药剂量对按一级过程吸收、米氏过程消除药物的血药浓度的峰值与达峰时间的影响。并据此讨论了利用较少的双剂量实验数据改善识别米氏参数的方法。

In this paper is analysed the influence of the dose on the peak value and peaK time of the pias-ma concentration vs time curve of drugs which obey first - order absorption and Michaelis -Menten elimination kinetics. A method usable to identify the Michaelis - Menton elimination p(?) rameters based on two sets of dose - response data is suggested