重组白细胞介素－1β对小鼠胚胎着床的影响

The Effect of rIL-1β on Embryo Implantation in Mice

本文报道了重组白细胞介素－１β（ｒＩＬ－１β）对小鼠胚胎着床的影响，并对其作用机理进行初步的探讨。研究证实，ｒＩＬ－１β能够有效地阻断妊娠第３、４天小鼠胚胎着床的发生，此外，ｒＩＬ－１β能致小鼠早期胚胎发育异常，运行滞缓，并改变小鼠胚泡植入阶段受卵巢激素调控的子宫内膜有丝分裂模式，还诱发着床前子宫腔白细胞浸润现象。上述结果表明，ｒＩＬ－１β对抗着床效应是多因素的协同作用。

The effect of rIL-1β on embryo development, transportation and implantation has been investigated in pregnant mice. It wag evident that after rIL-1β treatment at d3 or d4 of gestation, relation existed between the action of anti-implantation and the embryo development.The results also indieated that rIL-1β hindered the embryo transportation in the oviduct, resulting even in the disturbance of the proper implantation. In addition, the rIL-1β treatmgnt changed the mitotic pattern of endometrium cells at d5 of gestation, and induced leucocytic infiltration of endometrium.