458例胃粘膜活检的幽门螺杆菌和胃粘膜病变的关系

Relationship between Helicobacter Pylori and Pathological Lesiens in 458 Bioptic Specimens from gastric Mucosa in children

研究目的研究幽门螺杆菌（HP）与小儿胃粘膜病变的关系。研究方法对458例小儿胃窦部活检标本，光镜下，HE染色观察其病理组织学变化，Warthin－Starry染色观察有无HP感染。结果共检出HP152例，组织学正常者、慢性浅表性炎症及慢性萎缩性炎症中检出率分别为1．1％、4．3％及14．3％，其中慢性活动性炎症中HP检出率达80．2％，且多表现为局限性活动性病变。HP阳性胃粘膜内69．7％伴有固有膜内淋巴滤泡反应。结论HP感染与小儿慢性胃炎，尤其是慢性活动性胃炎关系密切，在病理组织学上HP相关性胃炎以慢性炎症伴活动性炎症（常以局限性为主）及固有膜内淋巴滤泡形成为特征。

Objectives To search for the relationship between HP and lesions of gastric mucosa of children.Methods Four hundred and fifty-eight bioptic specimens-from eastrie mueosa in children were strained with hematoxylin-eosin(HE)and Warthin-Starry for light microscopic study.Results HP was detected in 152 specimens. HP deteetable rate-in specimens with normal mucosa was 1. 1%, in compari-on with 42.3% in those with chronic superficial gastritis and 14. 3% in those with chronic atrophic gastrins .Specimens with chronic active gastritls, mostry manitesting local active lesions,had HP detectable rate of as high as 80.2%、69. 7% of the specimene with HP were found to have obvious lymph follicles reaction within lamina propria in their gastric mucosa.Conclusions There is a close relationship between HP infection and Pediatric chronic gastritis(especially chronic active gastritis). Histopathologically, HP-associated gastritis is characterized by chronic and local active inflamations, and tbe formation of lymph follicles within lamina propria.