环磷酰胺冲击治疗儿童系统性红斑狼疮(附6例报告)

Cyclophosphamide impulsion therapy for child patients with systemic lupus erythematosus (a report of 6 cases)

研究目的探讨儿童系统性红斑狼疮（SLE）的治疗方法及环磷酰胺（CTX）的疗效。治疗方法SLE患者共14例，CTX冲击治疗组6例，CTX每疗程（20～30）mg／kg，分2d静滴，疗程间隔15d，同时加用强的松1mg／kg。强的松治疗组8例，强的松2mg／（kg·d），连服8周后渐减量维持。结果CTX冲击治疗组8周内显效5例，有效1例，总有效率为100％。强的松治疗组仅1例完全缓解，5例有效，2例无效，总有效率为75％（P＜0．05）。结论静滴CTX加小剂量强的松口服是治疗SLE的最佳方法。

Objectives To search for the therapeutic methods of child patients with systemic lupus erythematosus (SLE) and the effect of cyclophosphamide (CTX) for SLE.Methods The 14 child patients with SLE were divided into two groups: CTX impulsion therapy group (6 cases) and prednisone therapy group (8 cases). The paticnts in CTX group were treated by CTX 20-30mg/kg, divided into two days for intravenous drip. There was a interval of 15 days between the two course of treatment. The prodnisone (1mg/kg) were used too at the same time. The patients in prednisone group were treated by prednisone, 2mg/kg. d, per os, tolal for 8 weeks, then reduced the dose gradually.Results The 5 cases get the obvious effect and 1 casc get the effect in 8 waeks in CTX group, total offective rate is 100%. one case is complete remission, 5 cases have effect and 2 cases are not effect, total effective rate is 75% (P<0.05).Conclusion CTX (intravenous drip) add the small dose of prednisone (per os) is the best therapeutic method for SLE.