慢性血吸虫病患者周围血淋巴细胞亚群测定的临床意义

CLINICAL SIGNIFICANCE OF LYMPHOCYTE SUBSETS IN PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC SCHISTOSOMIASIS

本文对３０例慢性血吸虫病患者，１４０例正常人和８２例各型病毒性肝炎患者作周围血Ｔ淋巴细胞亚群、细胞膜表面免疫球蛋白（ＳｍＩｇ）和Ｅ玫瑰花结形成细胞（ＥＲＦＣ）等检测。其结果表明：（１）慢性血吸虫病患者周围血Ｔ淋巴细胞的总Ｔ细胞（ＯＫＴ３）和辅助Ｔ细胞（ＯＫＴ４）及ＥＲＦＣ均明显低于正常人，而抑制杀伤Ｔ细胞（ＯＫＴ８）和ＳｍＩｇ却明显高于正常人，这可能与血吸虫发育过程中虫源性因子的释放有关。（２）急性和慢性病毒性肝炎患者与正常人比较，除ＥＲＦＣ明显较低外，其周围血ＯＫＴ３，ＯＫＴ４，ＯＫＴ８和ＳｍＩｇ均明显较高。血吸虫病患者和病毒性肝炎患者之间的ＯＫＴ８和ＳｍＩｇ无显著性差异而ＯＫＴ３和ＯＫＴ４则有不同，可能与其免疫病理有关。

T lymphocyte subsets, erythrocyte rosette forming cells (ERFC) and surface membrane mmunoglobulin (SmIg) in peripheral blood have been investigated in 30 patients with chronic schistosomiasis, 82 patients with different viral hepatits and 140 normal individuals. The reults showed: (1) The percentage of OKT3, OKT4 cells and ERFC in patients with chronic chistosomiasis were significantly lowered as compared with those of normal individuals, but the percentage of OKT8 cells and SmIg activity were higher than that in normal ones, which may be correlated with release of parasitogenic factor in development of schistosome. (2) The percentage of OKT3, OKT4, OKT8 cells and SmIg activity in patients with acute and chronic viral hepatitis were higher, but ERFC was lower than that in normal individuals significantly.The percentage of OKT4, OKT4 cells in viral hepatitis had a significant difference, but that of OKT8 cells and SmIg activity had no difference as compared with that in chronic schistosomiasis.