丙硫苯咪唑治疗长爪沙鼠泡球蚴病的效果

EFFECT OF ALBENDAZOLE IN ECHINOCOCCUS MULTILOCULARIS INFECTION IN JIRDS

腹腔接种多房棘球绦虫原头蚴感染长爪沙鼠２．５月后，用含０．２％丙硫苯咪唑（ＡＢＺ）药饵喂饲连续治疗２月（剂量２４０ｍｇ／ｋｇ／ｄ）．停药２月后剖杀结果：对照组泡球蚴平均湿重６．３±１．９ｇ，治疗组平均湿重０．９±０．２ｇ，明显低于对照组（Ｐ＜０．０１）。病理组织学检查显示治疗组泡球蚴囊泡明显塌陷、破裂、生发膜坏死脱落，原头蚴与子囊大片钙化．透射电镜检查发现生发膜结构完全破坏；残存原头蚴体细胞核膜断裂缺损，常染色质明显减少而异染色质显著增多成四块状；线粒体数目减少且肿胀、裂解；内质网与高尔基体明显肿胀、解聚、胞浆内可见大量球形空泡小体。表明ＡＢＺ对泡球蚴细胞有严重的破坏作用。

Twenty two jirds (Meriones unguiculatus)were infected with Echinococcus multilocularis by intraperitoneal inoculation of minced larval tissue containing protoscolices. Two and half months later, eleven jirds were treated with albendazole-medicated feed (0. 2%) for two months. Another eleven jirds were Lized as control. Two months posttherapy, all were sacrificed. The larval tissues of control jirds were found numerous alveoli with an average wet weight of 6. 3g, while that of treated jirds were shrinkened into small masses with an average wet weight of 0. 9g. Light and electronic-microscopic examinations of larval tissues showed alveoli with discrete, healthy protoscolices in control jirds. In the treated jirds, there were loss of structural integrity of alveoli and denudation of destructed germinal membranes. The protoscolices were mostly calcified. Mitochondria, Glogi apparatus and endoplasmic reticulum also showed marked degenerative changes. It is evident that albendazole therapy is effective in experimental E. multilocularis infection.