摘要
磷酸咯萘啶８００ｍｇ（基质）与复方磺胺多辛２片，伯喹４５ｍｇ（基质）伍用，在抗氯喹恶性疟流行区治疗恶性疟４２例，平均退热时间３９．０±１７．３ｈ，平均原虫无性体转阴时间４１．５±１３．６ｈ。服药后４８ｈ疟原虫无性体下降率为９７．６—１００％，２８天内复燃率为１０．３％（３／２９）；治后５天内配子体清除率达８７．５％。与５年前的疗效相似。显示该方案并不随恶性疟原虫对咯萘啶的敏感性下降而下降，当地临床观察证实恶性疟原虫对复方磺胺多辛、乙胺嘧啶的抗性率达４１．７％。
In 1993, 42 malaria cases from southern Yunnan endemic areas with P. falciparum resistant to chloroquine, amodiaquine, pipcraquinc and sulfadoxine/pyrimethamine were treated with combination of pyronaridine (800mg), sulfadoxine (1000mg), pyrimethamine (50mg) and primaquine (45mg) in 2 days. The results i. e. average defervescent time 39. 0±17. 3h, mean clearance time of asexual parasite 41. 5± 13. 6h, recrudescence rate 10. 3% (3/29) 28 days after treatment, and gamctocyte clearance rate 87. 5% 5 days after treatment showed no difference as compared with the effect of combination of pyronaridine (800mg),sulfadoxine (1000mg) and pyrimethamine (50mg) in 1987, though the sensitivity of P.falciparum was decreased to pyronaridine and sulfadoxine and sulfadoxine/pyrimethamine.
出处
《实用寄生虫病杂志》
1994年第3期31-33,共3页
Journal of Practical Parasitic Diseases
关键词
疟疾
磷酸咯萘啶
抗药性
疟原虫
治疗
Pyronaridine
multi-drug resistant
falciparum malaria
