卡托普利和尼群地平对老年高血压性左室肥厚影响的对比分析

Comparative study of Captopril and Nitrendipine on the left ventricular hypertrophy in the elderly hypertensives

用多普勤超声心动图随机分组比较卡托普利和尼群地平对６０例老年高血压性左室肥厚及舒张功能的影响。平均观察１２个月。卡托普利组空间隔、左室后壁分别减少２．４ｍｍ和１．２ｍｍ（Ｐ分别＜０．０１和０．０５），左室重量指数下降４４ｇ／ｍ２（Ｐ＜０．０１），左室舒张早期流速峰值（ＶＥ）显著增高（Ｐ＜０．０１），ＶＡ／ＶＥ显著降低（Ｐ＜０．０１），等容舒张期ＩＲＴ显著缩短（Ｐ＜０．０５）。尼群地中组室间隔肥厚减轻，左室重量指数下降及几项舒张功能参数改善幅度均小于卡托普利组（Ｐ均＜０．０５）。提示卡托普利逆转左室肥厚及改善舒张功能作用均优于尼群地平。

Left ventricular hypertrophy and diastolic function studied by coloured echocardiogarphy were compared in 60 elder hypertensive patients using Catopril (group C, n=30) and Nitrendipine (group N , n=30 .Both the everage treated duration were 12 month. The results showed the BP level of both the group C and group N had a significant reduction of IVST (12.9±1.6mm to 10.5±1. 4mm,P<0. 01),LVMI (156±42g/m to 114±22g/m, P<0.01), IRT (103±14ms to 94±16ms,P<0. 05),VA/VE(0.94±0. 23 to 0.61±0. 29,P 0.01). In group N these parameters were singnificatly changed (P<0. 05)too expect IRT. These more remarkable in group C than those in group N (P<0.05).