关于泡球蚴患者用丙硫咪唑治疗前后血清IgG,IgA,IgM水平的初步观察

PRELIMINARY OBSERVATIONS ON THE SERUM IMMUNOGLO-BULIN LEVELS IN PATIENTS WITH ALVEOLAR ECHINOCOCCOSIS BEFORE AND AFTER THERAPY WITH ALBENDAZOLE

本文用单向免疫扩散法比较了104例健康人和22例泡球蚴患者用丙硫咪唑治疗前和治疗期间的血清IgG、IgA和IgM水平。结果表明:治疗前和治疗期间,泡球蚴患者血清IgG和IgM水平均非常显著地高于健康人,但从治疗18个月后,P值由<0.01转为<0.05,而IgA水平呈上下波动。在用丙硫咪唑治疗1～3月期间,泡球蚴患者血清IgG水平升高,随后稳定下降,而IgM和IgA水平于整个治疗期间均处于波动状态。IgG-ELISA抗体滴度在治疗1个月时即明显下降,此后持续下降但呈上下波动。血清IgG浓度与IgG-ELISA抗体滴度间在治疗10～12个月以后有相关(r各为0.68,0.54,0.75,P<0.05～P<0.02),而IgA和IgM和IgG-ELISA抗体滴度间均无相关。

Serum IgG, IgA, IgM levels in 22 patients with alveolar echinococcosts before and after therapy with albendazole were compared with the mean levels of 104 healthy adults by single radial immuno-diffusion. The results indicate that before and during therapy, the mean IgG, IgM concentration in patients with alveolar echinococcosis was found to be significantly higher than the normal controls, but after 18 months of therapy, the statistic P value increased from<0.01 to <0.05. A increase of IgG was present in the 1-3 months period of treatment, and after that decreased consistently, but the IgA and IgM levels was fluctuating in the periods of therapy. A significant decrease of IgG-ELlSA antibody titer was found during the first month after therapy had been started. Subsequently the decline fluctuated. A correlation was found between the serum IgG levels and IgG-ELlSA antibody titers only after 10-12 months' therapy with albendazole (r=0.54, -0.75, P<0.05-P<0.02) .