摘要
对分枝杆菌多糖（Ｍｙｃｏｂａｃｔｅｒｉａｌｐｏｌｙｓａｃｃｈａｒｉｄｅｓ，ＭＰＳ）对环磷酰胺（ｃｙｃｌｏｐｈｏｓｐｈａｍｉｄｅ，ＣＰ）所致白细胞减少小鼠的影响进行了实验观察。小鼠腹腔注射ＣＰ，制作白细胞减少动物模型。实验组在给予ＣＰ的翌日，注射ＭＰＳ（５或２５μｇ／只·ｄ￣（－１）），连续４ｄ。隔日计数白细胞。与对照组比较，实验组白细胞数下降较少，回升迅速。结果提示ＭＰＳ有抑制ＣＰ所致白细胞降低及促进白细胞回升的作用。
We observed that Mycobacterial polysaccharides (MPS) had effects on the mice's leucocytopenia caused by cyclophosphamide(CP). We injected CP to the mice's abdominal cavities to make a leucocytopenia model. In experimental groups,the second day after the injection with CP,the mice were given MPS with 5 or 25 μg/mouse.d-1 for four days and the leukocytes were examined every other day.In comparison with the control groups,the experimental mice had a lower rate of leucocytopenia and recovered rapidly from it. The data reveals that MPS have functions on inhibiting the mice's leucocytopenia caused by CP and on promoting the recovery of leukocyte.
关键词
白细胞减少
分枝杆菌多糖
环磷酰胺
leucocytopenia
Mycobacterial polysaccharides
recovery of leukocyte
